https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Deep phenotyping of the neuroimaging and skeletal features in KBG syndrome: a study of 53 patients and review of the literature https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54396 Wed 21 Feb 2024 15:34:25 AEDT ]]> Abrogation of type-I interferon signalling alters the microglial response to Aß<sub>1-42</sub> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44488 1–42 exposure increases bioactive levels of type-I IFN produced by primary microglia alongside increased expression of type-I IFN related genes. Primary microglia isolated from brains of APPswePS1ΔE9 mice with ablated type-I IFN signalling show an increased phagocytic ability to uptake FITC-Aβ1–42. Correlative assessment of plaque sizes in aged APPswePS1ΔE9 mice with abrogated type-I IFN signalling show unchanged deposition levels. Microglia from these mice did however show alterations in morphology. This data further highlights the role of type-I IFN signalling within microglia and identifies a role in phagocytosis. As such, targeting both microglial and global type-I IFN signalling presents as a novel therapeutic strategy for AD management.]]> Fri 14 Oct 2022 09:11:35 AEDT ]]>